MS453 [2059892-29-2]
HY-116255
CAS Number2059892-29-2
Product group Chemicals
Molecular Weight385.46
Overview
- SupplierMedChem Express
- Product NameMS453 [2059892-29-2]
- Delivery Days Customer9
- CAS Number2059892-29-2
- CertificationResearch Use Only
- Molecular FormulaC20H27N5O3
- Molecular Weight385.46
- Scientific DescriptionMS453 is a potent and highly selective SETD8 inhibitor with an IC50 value of 804 nM. MS453 specifically modifies a cysteine residue close to the inhibitor binding site. MS453 is selective for 28 other methyltransferases. The crystal structure of MS453 reveals its binding mode to SETD8, providing an atomic-level view for the development of high-quality chemical probes for SETD8[1].
- SMILESCOC1=C(C=C(C2=C1)N=C(N=C2NCCCNC(C=C)=O)N3CCCC3)OC
- UNSPSC12352200