MS78
HY-149306
Estimated Purity99.38
Product group Chemicals
Molecular Weight1024.25
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Overview
- SupplierMedChem Express
- Product NameMS78
- Delivery Days Customer5
- CertificationResearch Use Only
- Estimated Purity99.38
- Molecular FormulaC57H66FN9O6S
- Molecular Weight1024.25
- Scientific DescriptionMS78 is an acetylation targeting chimera (AceTAC) that acetylates the p53 tumor suppressor protein. MS78 recruits histone acetyltransferase p300/CBP to acetylate the p53Y220C mutant. MS78 upregulates TRAIL apoptotic genes and downregulates DNA damage response pathways. MS78 contains a CBP/p300 binder, a p53Y220C binder and a linker[1].
- SMILESCC1=CSC(C2=CC=C(C3=C2)C4=C(N3CC)C=CC(CNCCOCCOCCOCCN5C=C(N=N5)COC6=C(C=C(C=C6)CCC7=NC8=C(N7CCN9CCOCC9)C=CC(C%10=C(ON=C%10C)C)=C8)F)=C4)=C1
- Storage Instruction2°C to 8°C
- UNSPSC12352200