MS934

Biorbyt

MS934

10

Research Use Only

C52H69F3IN7O6S

1104.127

MS934 (MS-934) is a VHL-recruiting MEK1/2 degrader (PROTAC) with HT29 DC50 of 18/9 nM for MEK1/2 degradation, respectively.MS934 is more potent at inhibiting the growth of HT-29, SK-MEL-28, H3122, and SUDHL1 cells. MS934 also displays good plasma exposure in mice.

FC1=CC=C(C(NOCCCCNCCCCCCCCCCCC(N[C@@H](C(C)(C)C)C(N2C(C(N[C@@H](C)C3=CC=C(C4=C(C)N=CS4)C=C3)=O)CC(O)C2)=O)=O)=O)C(NC5=CC=C(I)C=C5F)=C1F

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