Bio-Connect

MS9427 [2772613-37-1]

HY-147941
MedChem Express
CAS Number2772613-37-1
Product group Chemicals
Estimated Purity95.29
Molecular Weight993.47
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Overview

  • Supplier
    MedChem Express
  • Product Name
    MS9427 [2772613-37-1]
  • Delivery Days Customer
    10
  • CAS Number
    2772613-37-1
  • Certification
    Research Use Only
  • Estimated Purity
    95.29
  • Molecular Formula
    C48H58ClFN8O12
  • Molecular Weight
    993.47
  • Scientific Description
    MS9427 is a potent PROTAC EGFR degrader with Kds of 7.1 nM and 4.3 nM for EGFR WT and EGFR L858R, respectively. MS9427 selectively degrades the mutant but not the WT EGFR through both the ubiquitin/proteasome system (UPS) and autophagy/lysosome pathways. MS9427 potently inhibits the proliferation of NSCLC cells. MS9427 can be used for researching anticancer[1].
  • SMILES
    O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC(NCCOCCOCCOCCOCCOCCC(N4CCN(CCCOC5=CC6=C(NC7=CC=C(F)C(Cl)=C7)N=CN=C6C=C5OC)CC4)=O)=C3)=O
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12131703