MS9427 [2772613-37-1]
HY-147941
CAS Number2772613-37-1
Product group Chemicals
Estimated Purity95.29
Molecular Weight993.47
Overview
- SupplierMedChem Express
- Product NameMS9427 [2772613-37-1]
- Delivery Days Customer10
- CAS Number2772613-37-1
- CertificationResearch Use Only
- Estimated Purity95.29
- Molecular FormulaC48H58ClFN8O12
- Molecular Weight993.47
- Scientific DescriptionMS9427 is a potent PROTAC EGFR degrader with Kds of 7.1 nM and 4.3 nM for EGFR WT and EGFR L858R, respectively. MS9427 selectively degrades the mutant but not the WT EGFR through both the ubiquitin/proteasome system (UPS) and autophagy/lysosome pathways. MS9427 potently inhibits the proliferation of NSCLC cells. MS9427 can be used for researching anticancer[1].
- SMILESO=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC(NCCOCCOCCOCCOCCOCCC(N4CCN(CCCOC5=CC6=C(NC7=CC=C(F)C(Cl)=C7)N=CN=C6C=C5OC)CC4)=O)=C3)=O
- Storage Instruction2°C to 8°C
- UNSPSC12131703