MSA-2

MedChem Express

MSA-2 [129425-81-6]

10

129425-81-6

Research Use Only

99.81

C14H14O5S

294.32

MSA-2, a potent and orally available non-nucleotide STING agonist, is bound to STING as a noncovalent dimer with nanomolar affinity. MSA-2 shows EC 50 s of 8.3 and 24 microM for human STING isoforms WT and HAQ, respectively. MSA-2 stimulates interferon-beta secretion in tumors, induces tumor regression with durable antitumor immunity, and synergizes with anti-PD-1 in syngeneic mouse tumor models [1] [2] .

O=C(C1=CC(C(S1)=C2)=CC(OC)=C2OC)CCC(O)=O

2°C to 8°C

12352200