Immunofluorescence staining of Hela cells with CSB-PA015056LA01HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Immunofluorescence staining of Hela cells with CSB-PA015056LA01HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
MST1R Antibody
CSB-PA015056LA01HU
ApplicationsImmunoFluorescence, ELISA
Product group Antibodies
ReactivityHuman
TargetMST1R
Overview
- SupplierCusabio
- Product NameMST1R Antibody
- Delivery Days Customer20
- ApplicationsImmunoFluorescence, ELISA
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID4486
- Target nameMST1R
- Target descriptionmacrophage stimulating 1 receptor
- Target synonymsCD136, CDw136, NPCA3, PTK8, RON, SEA, p185-Ron, macrophage-stimulating protein receptor, MSP receptor, PTK8 protein tyrosine kinase 8, S13 avian erythroblastosis oncogene homolog, S13 erythroblastosis oncogene homolog, c-met-related tyrosine kinase
- HostRabbit
- IsotypeIgG
- Protein IDQ04912
- Protein NameMacrophage-stimulating protein receptor
- Scientific DescriptionReceptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand.
- ReactivityHuman
- Storage Instruction-20°C or -80°C
- UNSPSC41116161
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