MTA2 peptide

GeneTex

MTA2 peptide

9

The peptide is used for blocking the activity of anti-MTA2 (cat. no GTX28106). Incubating the peptide with equal volume of antibody for 30 min at 37C usually completely blocks the antibody activity in Western blotting.

Neutralisation/Blocking

Research Use Only

0.20 mg/ml

Unconjugated

MTA2

metastasis associated 1 family member 2

MTA1L1, PID, metastasis-associated protein MTA2, MTA1-L1 protein, metastasis -associated gene 1-like 1, metastasis associated gene family, member 2, metastasis-associated 1-like 1, metastasis-associated protein 2, p53 target protein in deacetylase complex

The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in the p53 pathway, including Chk2, p53R2, p53AIP1, Noxa, PIDD, and PID/MTA2, were recently discovered. The transcriptional activity of p53 is modulated by protein stability and acetylation. PID/MTA2, also termed MTA1-L1, was found to be a subunit of nucleosome remodeling and deacetylating (NRD/NuRD) complex. PID/MTA2 modulates the enzymatic activity of the histone deacetylase complex and its expression reduces the levels of acetylated p53. Deacetylation of p53 by PID/MTA2 represses p53-dependent transcriptional activation and modulates p53-mediated cell growth arrest and apoptosis. PID/MTA2 is ubiquitously expressed in human tissues.

-20°C

41116100

Human