Mu-6S-Palm-beta-Glc [229644-17-1]

TargetMol Chemicals

Mu-6S-Palm-beta-Glc [229644-17-1]

44

229644-17-1

Chemical

Research Use Only

Mu-6S-Palm-bèta-Glc

C32H48O8S

592.78

Mu-6S-Palm-beta-Glc is a fluorogenic substrate of palmitoyl-protein thioesterase (PPT, also known as CLN1), a lysosomal hydrolase that removes long-chain fatty acyl groups from modified cysteine residues in proteins. Upon cleavage by PPT/CLN1, it releases the fluorescent moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent, with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nM, increasing as pH decreases. This substrate is used in assays measuring PPT activity, commonly deficient in the neurodegenerative disorder known as infantile neuronal ceroid lipofuscinosis.

3 years

CC=1C=2C(=CC(O[C@@H]3O[C@H](CSC(CCCCCCCCCCCCCCC)=O)[C@@H](O)[C@H](O)[C@H]3O)=CC2)OC(=O)C1

-20°C

12352200