Murrangatin [37126-91-3]

TargetMol Chemicals

Murrangatin [37126-91-3]

999

37126-91-3

Chemical

Research Use Only

Murrangatin

C15H16O5

276.28

Murrangatin may be a valuable anti-tumor-promoting agent, it can significantly inhibit Epstein-Barr virus early antigen (EBV-EA) activation, and preserve the high viability of Raji cells, it also exhibits cytotoxicity against cholangiocarcinoma cell line, KKU-100. Murrangatin exhibits antibacterial activity against P. gingivalis (ATCC 33277). Murrangatin also shows soluble epoxide hydrolase inhibitory activity with IC50 values 13.9+/-6.5uM. Murrangatin and murracarpin may be a new backbone for developing inhibitors of cyclooxygenase 2, they show chondroprotective activity by downregulation of interleukin-1beta, tumor necrosis factoralpha, prostaglandins E2,and matrix metalloproteinases -13, and both of them may be a new backbone for developing inhibitors of cyclooxygenase 2.

3 years

COc1ccc2ccc(=O)oc2c1[C@@H](O)[C@@H](O)C(C)=C

-20°C

12352200