MY17

MedChem Express

MY17

5

Research Use Only

C21H13N5O3S3

479.55

MY17 is an inhibitor of protein tyrosine phosphatase 1B (PTP1B) (IC50=0.41+/-0.05 microM). MY17 alleviates palmitic acid (PA) -induced insulin resistance by up-regulating the expression of phosphorylated insulin receptor substrate (IRS1) and protein kinase B (AKT). By binding with PTP1B, MY17 can inhibit the activity of PTP1B, thereby improving insulin signaling and having anti-diabetic activity. MY17 can be used in the study of type 2 diabetes[1].

O=C(NC/1=O)SC1=C\C2=CC=C(C=C2)C(NC3=NN=C(S3)SCC4=CC=C(C=C4)C#N)=O

12352200