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Myelin basic protein antibody

GTX133108
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetMbp
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Overview

  • Supplier
    GeneTex
  • Product Name
    Myelin basic protein antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:5000-1:10000. IHC-P: 1:100-1:1000. IHC-Fr: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.5 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID17196
  • Target name
    Mbp
  • Target description
    myelin basic protein
  • Target synonyms
    C76307; goll; Golli-Mbp; Hmb; Hmbpr; jv; jve; mld; myelin A1 protein; myelin basic protein; myelin basic protein transcript variant X5; myelin deficient; R75289; shi; shiverer
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP04370
  • Protein Name
    Myelin basic protein
  • Scientific Description
    The protein encoded by the classic Mbp gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, Mbp-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long Mbp gene (otherwise called Golli-Mbp) that contains 3 additional exons located upstream of the classic Mbp exons. Alternative splicing from the Golli and the Mbp transcription start sites gives rise to 2 sets of Mbp-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-Mbp, spliced in-frame to 1 or more Mbp exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to Mbp aa sequence. The second family of transcripts contain only Mbp exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the Mbp transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. Mutation of the Mbp gene is associated with the shiverer and myelin deficient phenotypes in mouse. [provided by RefSeq, Jul 2008]
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Establishment of a brain cell line (FuB-1) from mummichog (Fundulus heteroclitus) and its application to fish virology, immunity and nanoplastics toxicology. Ruiz-Palacios M et al., 2020 Mar 15, Sci Total Environ
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  • Neurofascin-155 IgM autoantibodies in patients with inflammatory neuropathies. Doppler K et al., 2018 Nov, J Neurol Neurosurg Psychiatry
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  • Pseudotyped baculovirus is an effective gene expression tool for studying molecular function during axolotl limb regeneration. Oliveira CR et al., 2018 Jan 15, Dev Biol
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