MYF-03-176
HY-147136
Overview
- SupplierMedChem Express
- Product NameMYF-03-176 [2857937-59-6]
- Delivery Days Customer10
- CertificationResearch Use Only
- Estimated Purity99.72
- Molecular FormulaC19H18F4N4O2
- Molecular Weight410.37
- Scientific DescriptionMYF-03-176 is an orally active inhibitor of TEAD, and suppresses TEAD transcriptional activity with an IC50 of 11 nM. The IC50 values of MYF-03-176 for TEAD1, TEAD3, and TEAD4 are 47, 32, and 71 nM, respectively. MYF-03-176 inhibits hippo signaling defective malignant pleural mesothelioma (MPM) cells. MYF-03-176 shows strong antitumor efficacy in MPM mouse xenograft model[1][2][3].
- SMILESFC(F)(F)C1=CC=C(CO[C@@H]2CN(C(C(F)=C)=O)C[C@H]2NC3=NC=CC=N3)C=C1
- Storage Instruction2°C to 8°C
- UNSPSC12131703