MyoMed 205 [2614161-13-4]

TargetMol Chemicals

MyoMed 205 [2614161-13-4]

9

Research Use Only

C26H25N3O5S

491.56

MyoMed-205 is an inhibitor of MuRF1 (muscle ring finger protein 1) activity. It effectively prevents early diaphragm contractile dysfunction and atrophy following 12 hours of unilateral phrenic nerve denervation. By inhibiting MuRF1, MyoMed-205 reduces muscle protein ubiquitination and subsequent proteasome degradation. It also increases the protein levels of phosphorylated Akt (ser473), an essential signaling molecule for muscle growth and maintenance. MyoMed-205 is applicable in the research and treatment of diaphragm dysfunction and atrophy (DIDD) due to early disuse, particularly in clinical situations such as diaphragm paralysis or mechanical ventilation.

O=C1OC=2C=C(OCC3=CC=C(C=C3)C(=O)NCCNC(=O)NCC=4SC=CC4)C=CC2C(=C1)C

-20°C

12352200