N-Ac-gamma-Calicheamicin-AcBut-NHS ester

MedChem Express

N-Ac-gamma-Calicheamicin-AcBut-NHS ester

5

Research Use Only

95.62

C77H99IN6O28S3

1779.73

AcBut-N-Ac-gamma-Calicheamicin is an ADC cytotoxic payload that induces cell cycle arrest and apoptosis by causing DNA double-strand breaks. AcBut-N-Ac-gamma-Calicheamicin is primarily used in the synthesis of antibody-drug conjugates (ADC) and holds promise for research in the field of cancer, including acute lymphoblastic leukemia (ALL) and other hematological malignancies[1].

O[C@](CC1=O)(C#C/C=C\C#C2)/C(C([C@H]2O[C@@](O[C@H](C)[C@@H](NO[C@H](O[C@H](C)[C@H]3SC(C(C(C)=C(I)C(O[C@H](O[C@@H](C)[C@H](O)[C@H]4OC)[C@@H]4O)=C5OC)=C5OC)=O)C[C@@H]3O)[C@@H]6O)([H])[C@@H]6O[C@@](OC[C@@H]7N(CC)C(C)=O)([H])C[C@@H]7OC)=C1NC(OC)=O)=C/CSSC(C)(C)CC(N/N=C(C8=CC=C(OCCCC(ON(C9=O)C(CC9)=O)=O)C=C8)\C)=O

-20°C

12352200