N-Desmethyl-Apalutamide

MedChem Express

N-Desmethyl-Apalutamide [1332391-11-3]

9

1332391-11-3

Research Use Only

99.68

C20H13F4N5O2S

463.41

N-Desmethyl Apalutamide is an active metabolite of Apalutamide. N-Desmethyl Apalutamide is a less potent antagonist of the androgen receptor and is responsible for one-third of the activity of Apalutamide. The formation of N-Desmethyl Apalutamide mediated predominantly by CYP2C8 and CYP3A4. N-Desmethyl Apalutamide is moderate to strong CYP3A4 and CYP2B6 inducer and has an excellent plasma-proteins bound concentration [1] [2] [3] .

O=C(N)C1=CC=C(N(C(N(C2=CC(C(F)(F)F)=C(C#N)N=C2)C3=O)=S)C43CCC4)C=C1F

-20°C,2°C to 8°C

12352200