(+/-)-N-desmethyl Venlafaxine hydrochloride

Biorbyt

(+/-)-N-desmethyl Venlafaxine hydrochloride

10

93413-90-2

Research Use Only

98.00%

C16H26ClNO2

299.836

(+/-)-N-desmethyl Venlafaxine, a minor active metabolite of venlafaxine, serves as a selective norepinephrine and serotonin reuptake inhibitor (SNRI). Generated through the metabolization by the cytochrome P450 (CYP) isoform CYP3A4, it exhibits reuptake inhibition of norepinephrine and serotonin in rat synaptosome preparations, demonstrated by IC50 values of 4.7 and 1.6 microM, respectively. Clinically, it has been shown to counteract reserpine-induced hypothermia in mice, displaying efficacy at a minimum effective dose (MED) of 10 mg/kg.

Cl.CNCC(c1ccc(OC)cc1)C1(O)CCCCC1

-20°C

12352200