N-Desmethylclozapine-d8 [1189888-77-4]

MedChem Express

N-Desmethylclozapine-d8 [1189888-77-4]

10

1189888-77-4

Research Use Only

C17H9D8ClN4

320.85

N-Desmethylclozapine-d8 is the deuterium labeled N-Desmethylclozapine. N-Desmethylclozapine is a major active metabolite of the atypical antipsychotic agent Clozapine. N-Desmethylclozapine is a potent, allosteric and partial M1 receptors agonist (EC50=115 nM) and is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation. N-Desmethylclozapine is also a delta-opioid agonist[1][2].

ClC1=CC=C2NC3=CC=CC=C3C(N4C([2H])([2H])C([2H])([2H])NC([2H])([2H])C4([2H])[2H])=NC2=C1

2°C to 8°C

12352200