N-Desmethyltamoxifen (hydrochloride)

MedChem Express

N-Desmethyltamoxifen (hydrochloride) [15917-65-4]

10

15917-65-4

Research Use Only

99.93

C25H28ClNO

393.95

N-Desmethyltamoxifen hydrochloride is the major metabolite of tamoxifen in humans. N-Desmethyltamoxifen, a poor antiestrogen, is a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen. N-Desmethyltamoxifen hydrochloride is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation[1][2][3].

CC/C(C1=CC=CC=C1)=C(C2=CC=C(OCCNC)C=C2)\C3=CC=CC=C3.[H]Cl

2°C to 8°C

12352200