N-didesmethyl Loperamide

Biorbyt

N-didesmethyl Loperamide

10

66164-06-5

Research Use Only

98.00%

C27H29ClN2O2

448.98

N-didesmethyl Loperamide, an active metabolite of the peripheral micro1-opioid receptor agonist loperamide, impedes electrically induced contractions in isolated guinea pig myenteric plexus (IC50 = 370 nM) and enhances the sensitivity of a chloroquine-resistant P. falciparum strain to chloroquine (EC50 = 482 nM). Notably, it achieves this without causing toxicity in A-10 vascular smooth muscle cells (IC50 = > 10,000 nM).

NC(C(C1=CC=CC=C1)(C2=CC=CC=C2)CCN3CCC(C4=CC=C(Cl)C=C4)(O)CC3)=O

-20°C

12352200