N-Didesmethyladitoprim

MedChem Express

N-Didesmethyladitoprim

999

Research Use Only

C13H17N5O2

275.31

N-Didesmethyladitoprim is a metabolite of Aditoprime (HY-139743). Aditoprime is a selective bacterial dihydrofolate reductase (DHFR) inhibitor with IC50s of 47 and 520 nM for E.coli and L.casei DHFR , respectively. Aditoprime inhibits the transformation of dihydrofolic acid to tetrahydrofolic acid. Aditoprime has a broad-spectrum antibacterial activity and excellent pharmacokinetics[1][2][3][4].

NC1=NC=C(CC2=CC(OC)=C(C(OC)=C2)N)C(N)=N1

12352200