N-Methylmesoporphyrin IX [142234-85-3]

MedChem Express

N-Methylmesoporphyrin IX [142234-85-3]

10

142234-85-3

Research Use Only

99.65

C35H40N4O4

580.72

N-Methylmesoporphyrin IX (NMM), a widely used G-quadruplex DNA specific fluorescent binder, is an efficient probe for monitoring Abeta fibrillation. N-Methylmesoporphyrin IX is an in situ inhibitor and an ex situ monitor for Abeta amyloidogenesis both in vitro and in cells. N-Methylmesoporphyrin IX is sensitive to G-quadruplexes DNA but has no response to duplexes, triplexes and single-stranded forms DNA. N-Methylmesoporphyrin IX is nonfluorescent alone or in monomeric Abeta environments, but emits strong fluorescence through stacking with the Abeta assemblies[1].

O=C(O)CCC1=C2/C=C3C(CCC(O)=O)=C(C)C(/C=C(N/4C)/C(CC)=C(C)C4=C\C5=N/C(C(C)=C5CC)=C\C(N2)=C1C)=N/3.O=C(O)CCC6=C7/C=C8C(CCC(O)=O)=C(C)C(/C=C(N/9)/C(CC)=C(C)C9=C\C%10=N/C(C(C)=C%10CC)=C\C(N7C)=C6C)=N/8

-20°C

12162000