N-(p-Tosyl)-GPR-pNA (acetate)

MedChem Express

N-(p-Tosyl)-GPR-pNA (acetate) [86890-95-1]

5

86890-95-1

Research Use Only

C28H38N8O9S

662.71

N-(p-Tosyl)-GPR-pNA acetate (Chromozym-TH) is a chromogenic substrate targeting the synthetic peptides Hirunorm IV and Hirunorm V and can be used to detect the dissociation constants (KI) of both peptides. Hirunorm IV and Hirunorm V are reversible inhibitors of amidolytic thrombin activity. By varying the peptide concentration at a fixed concentration of the chromogenic substrate N-(p-Tosyl)-GPR-pNA acetate, the dissociation constants determined were 0.134 nM (Hirunorm IV) and 0.245 nM (Hirunorm V)[1].

O=C([C@H](CCC1)N1C(CN[S](=O)(C(C=C2)=CC=C2C)=O)=O)N[C@@H](CCCNC(N)=N)C(NC(C=C3)=CC=C3[N](=O)=O)=O.CC(O)=O

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