N-Succinimidyl 3-(2-pyridyldithio)propionate

Chemodex

N-Succinimidyl 3-(2-pyridyldithio)propionate

10

68181-17-9

Research Use Only

>97%

Chemical. CAS: 68181-17-9. Formula: C12H12N2O4S2. MW: 312.36. Soluble in acetone (50mg/ml), DMF or methanol. N-Succinimidyl 3-(2-pyridyldithio)propionate is a heterobifunctional cross-linking reagent with amine and sulfhydryl reactivity. It is typically coupled initially to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5). Second coupling specific for molecules containing free sulfhydryl by thiol-disulfide exchange buffered at pH 8.0 (7.5-8.5). Alternately, this reagent may be used as a protected thiolating reagent following initial coupling and reduction of linker. It incorporates four atom linker. N-Succinimidyl 3-(2-pyridyldithio)propionate (SPDP) is useful for the preparation of enzyme immunoconjugates and hapten carrier molecule conjugates. It has been used for antibody conjugation and as a protein cross-linker. It is also a glutathione cleavable ADC linker used for the antibody-drug conjugates (ADCs). - N-Succinimidyl 3-(2-pyridyldithio)propionate is a heterobifunctional cross-linking reagent with amine and sulfhydryl reactivity. It is typically coupled initially to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5). Second coupling specific for molecules containing free sulfhydryl by thiol-disulfide exchange buffered at pH 8.0 (7.5-8.5). Alternately, this reagent may be used as a protected thiolating reagent following initial coupling and reduction of linker. It incorporates four atom linker. N-Succinimidyl 3-(2-pyridyldithio)propionate (SPDP) is useful for the preparation of enzyme immunoconjugates and hapten carrier molecule conjugates. It has been used for antibody conjugation and as a protein cross-linker. It is also a glutathione cleavable ADC linker used for the antibody-drug conjugates (ADCs).

-20°C,2°C to 8°C

12352200