N1,N11-Diethylnorspermine (tetrahydrochloride)

MedChem Express

N1,N11-Diethylnorspermine (tetrahydrochloride) [156886-85-0]

10

156886-85-0

Research Use Only

98.0

C13H36Cl4N4

390.26

N1, N11-Diethylnorspermine tetrahydrochloride (DENSPM tetrahydrochloride) is a potent anticancer agent. N1,N11-Diethylnorspermine tetrahydrochloride activates polyamine catabolism and downregulates mTOR protein. N1,N11-Diethylnorspermine tetrahydrochloride induces the release of cytochrome c from mitochondria, resulting in activation of caspase 3 . N1,N11-Diethylnorspermine tetrahydrochloride kills glioblastoma multiforme (GBM) through induction of SSAT (spermidine/spermine N1-acetyltransferase) coupled with H 2 O 2 production [1] [2] [3] [4] [5] [6] .

CCNCCCNCCCNCCCNCC.[H]Cl.[H]Cl.[H]Cl.[H]Cl

2°C to 8°C

12352200