Nafazatrom [59040-30-1]
HY-121586
CAS Number59040-30-1
Product group Chemicals
Molecular Weight268.31
Overview
- SupplierMedChem Express
- Product NameNafazatrom [59040-30-1]
- Delivery Days Customer5
- CAS Number59040-30-1
- CertificationResearch Use Only
- Molecular FormulaC16H16N2O2
- Molecular Weight268.31
- Scientific DescriptionNafazatrom (Bay g 6575) is an orally active cardioprotective agent that protects against ischemic damage. Nafazatrom dose-dependently inhibits neutrophil aggregation, superoxide anion generation, arachidonic acid metabolism, and to a lesser extent the release of beta-glucosidase, platelet aggregation or arachidonic acid in vitro. Acid metabolism has no significant effect. In a dog ischemia-reperfusion model, Nafazatrom (10 mg/kg; po) reduced infarct size and the occurrence of arrhythmias and rescued ischemic myocardial function without affecting any hemodynamic changes. The basis of Nafazatroms cardioprotection may be inhibition of neutrophil function and cellular infiltration in vitro[1].
- SMILESO=C1N(N=C(C1)C)CCOC2=CC=C3C=CC=CC3=C2
- UNSPSC12352200