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ICC/IF analysis of HeLa cells using GTX12116 NAK / TBK1 antibody [108A429]. Green : primary antibody Red : Tubulin Blue : DAPI Dilution : 1:10
ICC/IF analysis of HeLa cells using GTX12116 NAK / TBK1 antibody [108A429]. Green : primary antibody Red : Tubulin Blue : DAPI Dilution : 1:10
ICC/IF analysis of HeLa cells using GTX12116 NAK / TBK1 antibody [108A429]. Green : primary antibody Red : Tubulin Blue : DAPI Dilution : 1:10

NAK / TBK1 antibody [108A429]

GTX12116
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityBovine, Canine, Human, Mouse, Rat
TargetTBK1
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Overview

  • Supplier
    GeneTex
  • Product Name
    NAK / TBK1 antibody [108A429] - Overexpression Validated
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1 - 2 microg/ml. ICC/IF: 1:20. IHC-P: 1:20 - 1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    108A429
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID29110
  • Target name
    TBK1
  • Target description
    TANK binding kinase 1
  • Target synonyms
    FTDALS4; IIAE8; NAK; NF-kappa-B-activating kinase; NF-kB-activating kinase; serine/threonine-protein kinase TBK1; T2K
  • Host
    Mouse
  • Isotype
    IgG1
  • Protein IDQ9UHD2
  • Protein Name
    Serine/threonine-protein kinase TBK1
  • Scientific Description
    The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. For example, the protein can form a complex with the IKB protein TANK and TRAF2 and release the NFKB inhibition caused by TANK. [provided by RefSeq]
  • Reactivity
    Bovine, Canine, Human, Mouse, Rat
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1. Zhao B et al., 2019 May, Nature
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  • Rebamipide suppresses TLR-TBK1 signaling pathway resulting in regulating IRF3/7 and IFN-alpha/beta reduction. Ogasawara N et al., 2011 Mar, J Clin Biochem Nutr
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