NALCN Antibody (OASE00265)

Aviva Systems Biology

NALCN Antibody (OASE00265)

23

ImmunoFluorescence, Western Blot, ImmunoCytoChemistry

Research Use Only

Monoclonal

S187-7

1 mg/ml

Unconjugated

Liquid PBS (pH 7.4) with 50% glycerol and 0.09% sodium azide

Nalcn

sodium leak channel, non-selective

Vgcnl1, sodium leak channel NALCN, brain voltage-gated cation channel, four domain-type voltage-gated ion channel alpha-1 subunit, rb21-channel, sodium leak channel non-selective protein, voltage gated channel like 1, voltage gated channel-like protein 1

Mouse

IgG1

NALCN (sodium leak channel non-selective protein), alsoknown as CanIon or VGCNL1 (voltage gated channel-like protein 1), is a 1738 amino acid multi-pass membrane protein that belongs to the cation-nonselective channel family. NALCN is highly conserved in mammals and is widely expressed in the central nervous system. Activated by NK-1R, NALCN is a voltage-independent, nonselective cation channel which is permeable to sodium, potassium and calcium ions. NALCN is responsible for background sodium ion leak conductance in neurons and regulates basal excitability of the nervous systems. Defects of NALCN in mice causes disruption in respiratory rhythm and death occurs within 24 hours of birth. Three isoforms of NALCN exists due to alternative splicing events.

-20°C

12352203