Nampt Antibody

Cusabio

Nampt Antibody

20

Western Blot, ELISA

Research Use Only

Polyclonal

Unconjugated

Nampt

nicotinamide phosphoribosyltransferase

Pbef, Pbef1, nicotinamide phosphoribosyltransferase, NAmPRTase, pre-B-cell colony enhancing factor 1, pre-B-cell colony-enhancing factor 1 homolog, visfatin

Rabbit

IgG

Nicotinamide phosphoribosyltransferase

Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-ARNTL/BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression.

Human, Rat

-20°C or -80°C

41116161