NAMPT degrader-1

MedChem Express

NAMPT degrader-1 [3011778-39-2]

10

Research Use Only

C56H68ClN9O5S2

1046.78

NAMPT degrader-1 (Compound A3), an autophagosome-tethering compound (ATTEC), is an nicotinamide phosphoribosyltransferase (NAMPT) degrader with an IC50 of 0.023 microM. NAMPT degrader-1 significantly induces the degradation of NAMPT through the autophagy-lysosomal pathway and shows excellent cellular antitumor potency[1].

O=C1N(C([C@@H](C(C)C)N(CCCNC(CCCCCCCCN2CCN(S(C3=CC=C(NC(NCC4=CC=CN=C4)=S)C=C3)(=O)=O)CC2)=O)C(C5=CC=C(C=C5)C)=O)=NC6=CC(Cl)=CC=C61)CC7=CC=CC=C7

12131703