NAMPT inhibitor-linker 1 [2241019-57-6]

MedChem Express

NAMPT inhibitor-linker 1 [2241019-57-6]

10

2241019-57-6

Research Use Only

Monoclonal

99.27

C36H37FN6O6

668.71

NAMPT inhibitor-linker 1 is a agent-linker conjugates for ADC, composed of an NAMPT inhibitor as a payload, and a linker. ADC-3 consists of an NAMPT inhibitor-linker 1 and an anti-c-Kit monoclonal antibody, exihibits potent activity against c-Kit expressing cell lines such as GIST-T1 and NCI-H526 cells, with IC50s of <3 pM and 9 pM, respectively.

FC1=CC(NC([C@@H]2[C@H](C2)C3=CN=CC=C3)=O)=CC=C1CNC(C4=CC=C(N5CCN(C(CCOCCN6C(C=CC6=O)=O)=O)CC5)C=C4)=O

-20°C

41115800