NAMPT inhibitor-linker 2 [2241014-82-2]

MedChem Express

NAMPT inhibitor-linker 2 [2241014-82-2]

10

2241014-82-2

Research Use Only

Monoclonal

99.35

C34H33FN6O5

624.66

NAMPT inhibitor-linker 2 is a agent-linker conjugates for ADC, composed of an NAMPT inhibitor as a payload, and a linker. ADC-4 consists of an NAMPT inhibitor-linker 2 and an anti-c-Kit monoclonal antibody, exihibits potent activity against c-Kit expressing cell lines such as GIST-T1 and NCI-H526, with IC50s of <7 pM and 40 pM, respectively.

FC1=CC(NC([C@@H]2[C@H](C2)C3=CN=CC=C3)=O)=CC=C1CNC(C4=CC=C(N5CCN(C(CCN6C(C=CC6=O)=O)=O)CC5)C=C4)=O

-20°C,2°C to 8°C

41115800