Insulin-mimetic effects on stimulated differentiating 3T3-L1 cells. 10microg/ml Nampt (mouse) (rec.) (His) (Prod. No. AG-40A-0017) or human insulin was added to differentiating 3T3-L1 cells that had been stimulated with 1microM dexamethasone and 0.5m
Nampt (Visfatin/PBEF) (mouse) (rec.) (His)
AG-40A-0017
Overview
- SupplierAdipoGen Life Sciences
- Product NameNampt (Visfatin/PBEF) (mouse) (rec.) (His)
- Delivery Days Customer10
- CertificationResearch Use Only
- Estimated Purity>90%
- Protein IDQ99KQ4
- Protein NameNicotinamide phosphoribosyltransferase
- Scientific DescriptionNicotinamide phosphoribosyltransferase (Nampt; pre-B cell colony-enhancing factor; PBEF; Visfatin) is an adipokine that is localized to the bloodstream and has various functions, including the promotion of vascular smooth muscle cell maturation and inhibition of neutrophil apoptosis. It activates insulin receptor and has insulin-mimetic effects, lowering blood glucose and improving insulin sensitivity. The protein is highly expressed in visceral fat and serum levels of the protein correlate with obesity. Recently NAMPT extracellular (eNAMPT) has been shown to be secreted from macrophages in muscles and to triggers a proliferative signal of muscle stem cell (MusC) by binding to CCR5 located at the surface receptor of MusC. - Protein. Mouse Nampt (visfatin/PBEF) (aa 1-491) is fused at the C-terminus to a His-tag. Source: E. coli. Endotoxin content: <1EU/microg purified protein (LAL test; Lonza). Lyophilized from 0.2microm-filtered solution in PBS, pH 7.2. Purity: >90% (SDS-PAGE). Nicotinamide phosphoribosyltransferase (Nampt; pre-B cell colony-enhancing factor; PBEF; Visfatin) is an adipokine that is localized to the bloodstream and has various functions, including the promotion of vascular smooth muscle cell maturation and inhibition of neutrophil apoptosis. It activates insulin receptor and has insulin-mimetic effects, lowering blood glucose and improving insulin sensitivity. The protein is highly expressed in visceral fat and serum levels of the protein correlate with obesity.
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC12352202