Bio-Connect

NAMPT/IDO1-IN-1

HY-148572
MedChem Express
Molecular Weight559.39
Product group Chemicals
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Overview

  • Supplier
    MedChem Express
  • Product Name
    NAMPT/IDO1-IN-1 [2247884-06-4]
  • Delivery Days Customer
    10
  • Certification
    Research Use Only
  • Molecular Formula
    C23H24BrFN8O3
  • Molecular Weight
    559.39
  • Scientific Description
    NAMPT/IDO1-IN-1 is an orally active dual inhibitor of NAMPT and IDO1 with IC50s of 57.7 nM and 233 nM, respectively. NAMPT/IDO1-IN-1 blocks NAD+ biosynthesis, inhibits proliferation and migration of Paclitaxel (HY-B0015)- and FK866 (HY-50876)-resistant NSCLC cell lines (A549/R cells). NAMPT/IDO1-IN-1 has shown antitumor effects in mice and enhanced A549/R cell sensitivity to paclitaxel[1].
  • SMILES
    BrC(C=C1N/C(C2=NON=C2NCCCCCCNC(C3=CN4C(C=C3)=NC=C4)=O)=N\O)=C(C=C1)F
  • UNSPSC
    12131703