NAMPT/IDO1-IN-1
HY-148572
Overview
- SupplierMedChem Express
- Product NameNAMPT/IDO1-IN-1 [2247884-06-4]
- Delivery Days Customer10
- CertificationResearch Use Only
- Molecular FormulaC23H24BrFN8O3
- Molecular Weight559.39
- Scientific DescriptionNAMPT/IDO1-IN-1 is an orally active dual inhibitor of NAMPT and IDO1 with IC50s of 57.7 nM and 233 nM, respectively. NAMPT/IDO1-IN-1 blocks NAD+ biosynthesis, inhibits proliferation and migration of Paclitaxel (HY-B0015)- and FK866 (HY-50876)-resistant NSCLC cell lines (A549/R cells). NAMPT/IDO1-IN-1 has shown antitumor effects in mice and enhanced A549/R cell sensitivity to paclitaxel[1].
- SMILESBrC(C=C1N/C(C2=NON=C2NCCCCCCNC(C3=CN4C(C=C3)=NC=C4)=O)=N\O)=C(C=C1)F
- UNSPSC12131703