Nanog antibody [GT3312]

GeneTex

Nanog antibody [GT3312]

9

WB: 1:500-1:3000. FACS: 1:50-1:200. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Flow Cytometry, ImmunoFluorescence, Western Blot, ImmunoCytoChemistry

Research Use Only

Monoclonal

GT3312

1 mg/ml

Unconjugated

NANOG

Nanog homeobox

homeobox protein NANOG; homeobox transcription factor Nanog; homeobox transcription factor Nanog-delta 48

Mouse

IgG2b

Homeobox protein NANOG

Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes (By similarity). Acts as a transcriptional activator or repressor (By similarity). Binds optimally to the DNA consensus sequence 5-TAAT[GT][GT]-3 or 5-[CG][GA][CG]C[GC]ATTAN[GC]-3 (By similarity). When overexpressed, promotes cells to enter into S phase and proliferation.

Human, Mouse

-20°C or -80°C,2°C to 8°C

12352203