Narazaciclib

MedChem Express

Narazaciclib [1357470-29-1]

10

1357470-29-1

99.12

C24H27N7O

429.52

Narazaciclib (ON123300), a strong and brain-penetrant [1] multi-kinase inhibitor, inhibits CDK4 ( IC 50 =3.9 nM), Ark5 ( IC 50 =5 nM), PDGFRbeta ( IC 50 =26 nM), FGFR1 ( IC 50 =26 nM), RET ( IC 50 =9.2 nM), and FYN ( IC 50 =11 nM). Single agent Narazaciclib causes a dose-dependent suppression of phosphorylation of Akt as well as activation of Erk in brain tumors [2] . Narazaciclib inhibits CDK6 with an IC 50 of 9.82 nM [3] .

N#CC1=CC2=CN=C(NC3=CC=C(N4CCN(C)CC4)C=C3)N=C2N(C5CCCC5)C1=O

-20°C,2°C to 8°C

12352200