Bio-Connect
Nargenicin [70695-02-2]

Nargenicin [70695-02-2]

T36417
TargetMol Chemicals
CAS Number70695-02-2
Product group Chemicals
Molecular Weight515.6
Sign in to order and to see your custom pricing.
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    Nargenicin [70695-02-2]
  • Delivery Days Customer
    16
  • CAS Number
    70695-02-2
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Chemical Name
    Nargenicin
  • Molecular Formula
    C28H37NO8
  • Molecular Weight
    515.6
  • Scientific Description
    Nargenicin is a macrolide antibiotic that selectively inhibits the growth of S. aureus, methicilin resistant S. aureus (MRSA), and M. luteus (MICs = 0.6, 0.3, and 2.5 microg/ml, respectively) over a panel of 11 Gram-positive and Gram-negative bacteria (MICs = >80 microg/ml). [1] It dose-dependently inhibits S. aureus DnaE in the presence of DNase I-activated DNA and E. coli DnaE when used at concentrations of 0.00001-0.1 and 0.01-100 microg/mL, respectively. [2] In murine BV-2 microglial cells, nargenicin (1 microM) inhibits cytokine expression and nitric oxide production induced by LPS.[3] Nargenicin (200 microM), when used in combination with 1,25-dihydroxyvitamin D3 or all-trans retinoic acid , reduces cell proliferation by 37-47% and increases cell differentiation by 82-85% in HL-60 human myeloid leukemia cells.[4]
  • Shelf life instruction
    3 years
  • SMILES
    [H][C@]12C=C[C@]3([H])C[C@H](OC)C(=O)O[C@]([H])([C@@H](C)O)[C@H](C)\C=C(C)\[C@]33O[C@H]1[C@H](OC(=O)c1ccc[nH]1)[C@H](C)[C@@H](O)[C@]23[H]
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200