NAS-181 (dimesylate)

MedChem Express

NAS-181 (dimesylate) [1217474-40-2]

10

1217474-40-2

Research Use Only

98.44

C21H34N2O10S2

538.63

NAS181 is a potent and selective antagonist of rat 5-HT 1B receptor, with a K i of 47 nM. NAS181 shows 13-fold selectivity for r5-HT 1B over bovine 5-HT 1B receptor (K i =630 nM). NAS181 increases the 5-HT turnover and the synaptic concentration of 5-HT by inhibiting terminal r5-HT 1B autoreceptors [1] [2] .

CS(=O)(O)=O.CS(=O)(O)=O.[C@H]1(COC2=CC=CC3=C2OCC(CN4CCOCC4)=C3)CNCCO1

2°C to 8°C

12352200