Natalizumab [189261-10-7]

MedChem Express

Natalizumab [189261-10-7]

10

Research Use Only

Monoclonal

99.10

Natalizumab is a recombinant, humanized IgG4 monoclonal antibody, binds to alpha4beta1-integrin and blocks its interaction with vascular cell adhesion molecule-1 (VCAM-1). Natalizumab can be used for the treatment of relapsing remitting multiple sclerosis and Crohns disease. Natalizumab is also the first targeted therapy which blocks an essential mechanism for lymphocyte entry to the CNS and thus prevents acute demyelinating relapses[1].

2°C to 8°C

12352203