Navitoclax

MedChem Express

Navitoclax [923564-51-6]

10

923564-51-6

99.97

C47H55ClF3N5O6S3

974.61

Navitoclax (ABT-263) is a potent and orally active Bcl-2 family protein inhibitor that binds to multiple anti-apoptotic Bcl-2 family proteins, such as Bcl-x L , Bcl-2 and Bcl-w, with a K i of less than 1 nM [1] .

O=S(C1=CC(S(NC(C2=CC=C(N3CCN(CC4=C(CCC(C)(C4)C)C5=CC=C(Cl)C=C5)CC3)C=C2)=O)(=O)=O)=CC=C1N[C@H](CCN6CCOCC6)CSC7=CC=CC=C7)(C(F)(F)F)=O

-20°C,2°C to 8°C

12352200