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ProductsBack/NBI 35965 (methanesulfonate)

NBI 35965 (methanesulfonate)

HY-103378

CAS Number603151-83-3

Product group Chemicals

Molecular Weight497.44

Overview

Supplier
MedChem Express
Product Name
NBI 35965 (methanesulfonate)
Delivery Days Customer
5
CAS Number
603151-83-3
Certification
Research Use Only
Molecular Formula
C22H26Cl2N4O3S
Molecular Weight
497.44
Scientific Description
NBI 35965 methanesulfonate is a selective, orally active and brain-penetrant corticotropin-releasing factor receptor 1 (CRF1) antagonist with a Ki value of 4 nM and a pKi value of 8.5. NBI 35965 methanesulfonate does not inhibit CRF2. NBI 35965 methanesulfonate reduces CRF or stress-induced adrenocorticotropic hormone (ACTH) production in vivo with pIC50 values of 7.1 and 6.9, respectively. NBI 35965 methanesulfonate shows anxiolytic effects[1][2].
SMILES
CC1=CC2=C3N(N=C(C4=CC=C(Cl)C=C4Cl)C3=N1)C[C@H](CC)N2CC5CC5.OS(=O)(C)=O
UNSPSC
12352200

MSDS

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