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NBI 35965 (methanesulfonate)

HY-103378
MedChem Express
CAS Number603151-83-3
DownloadMSDS
Product group Chemicals
Molecular Weight497.44
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Overview

  • Supplier
    MedChem Express
  • Product Name
    NBI 35965 (methanesulfonate) [603151-83-3]
  • Delivery Days Customer
    5
  • CAS Number
    603151-83-3
  • Certification
    Research Use Only
  • Molecular Formula
    C22H26Cl2N4O3S
  • Molecular Weight
    497.44
  • Scientific Description
    NBI 35965 methanesulfonate is a selective, orally active and brain-penetrant corticotropin-releasing factor receptor 1 (CRF1) antagonist with a K i value of 4 nM and a pK i value of 8.5. NBI 35965 methanesulfonate does not inhibit CRF2. NBI 35965 methanesulfonate reduces CRF or stress-induced adrenocorticotropic hormone (ACTH) production in vivo with pIC 50 values of 7.1 and 6.9, respectively. NBI 35965 methanesulfonate shows anxiolytic effects [1] [2] .
  • SMILES
    CC1=CC2=C3N(N=C(C4=CC=C(Cl)C=C4Cl)C3=N1)C[C@H](CC)N2CC5CC5.OS(=O)(C)=O
  • UNSPSC
    12352200