NCK1 Antibody

Cusabio

NCK1 Antibody

20

Western Blot, ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

NCK1

NCK adaptor protein 1

NCK, NCKalpha, nck-1, SH2/SH3 adapter protein NCK1, NCK adapter protein 1, NCK tyrosine kinase, SH2/SH3 adapter protein NCK-alpha, SH2/SH3 adaptor protein NCK-alpha, cytoplasmic protein NCK1, melanoma NCK protein, non-catalytic region of tyrosine kinase

Rabbit

IgG

Cytoplasmic protein NCK1

Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors.

Human, Rat

-20°C or -80°C

41116161