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ProductsBack/NDI-091143 [2375840-87-0]

NDI-091143 [2375840-87-0]

Research Use Only
HY-127111
MedChem Express
CAS Number2375840-87-0
DownloadMSDS
Product group Chemicals
Estimated Purity99.88
Molecular Weight453.84
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Overview

  • Supplier
    MedChem Express
  • Product Name
    NDI-091143 [2375840-87-0]
  • Delivery Days Customer
    10
  • CAS Number
    2375840-87-0
  • Certification
    Research Use Only
  • Estimated Purity
    99.88
  • Molecular Formula
    C20H14ClF2NO5S
  • Molecular Weight
    453.84
  • Scientific Description
    NDI-091143 is a potent and high-affinity human ATP-citrate lyase (ACLY) inhibitor with an IC50 of 2.1 nM (ADP-Glo assay), a Ki of 7.0 nM and a Kd of 2.2 nM. NDI-091143 inhibits ACLY catalysis allosterically, by stabilizing large conformational changes in the citrate domain that indirectly block the binding and recognition of citrate[1].
  • SMILES
    O=C(OC)C1=CC(S(=O)(NC2=CC(C3=CC=CC=C3)=C(F)C=C2F)=O)=C(O)C(Cl)=C1
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200