NDI-091143

AbMole BioScience

NDI-091143

9

2375840-87-0

Chemical

Research Use Only

C20H14ClF2NO5S

453.84

NDI-091143 is a novel potent inhibitor of human ATP-citrate lyase with an IC50 of 2.1 nM (ADP-Glo assay), a Ki of 7.0 nM and a Kd of 2.2 nM. NDI-091143 inhibits ACLY catalysis allosterically, by stabilizing large conformational changes in the citrate domain that indirectly block the binding and recognition of citrate.

COC(=O)C1=CC(=C(O)C(=C1)[S](=O)(=O)NC2=C(F)C=C(F)C(=C2)C3=CC=CC=C3)Cl

12352200