Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA015609LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA015609LA01HU at dilution of 1:100
NDP Antibody
CSB-PA015609LA01HU
ApplicationsELISA, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman
TargetNDP
Overview
- SupplierCusabio
- Product NameNDP Antibody
- Delivery Days Customer20
- ApplicationsELISA, ImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID4693
- Target nameNDP
- Target descriptionnorrin cystine knot growth factor NDP
- Target synonymsEVR2, FEVR, ND, norrin, NDP, norrin cystine knot growth factor, Norrie disease (pseudoglioma), X-linked exudative vitreoretinopathy 2 protein, norrie disease protein
- HostRabbit
- IsotypeIgG
- Protein IDQ00604
- Protein NameNorrin
- Scientific DescriptionActivates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction.
- ReactivityHuman
- Storage Instruction-20°C or -80°C
- UNSPSC41116161
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