Necrostatin 2 (S enantiomer) [852391-20-9]

MedChem Express

Necrostatin 2 (S enantiomer) [852391-20-9]

10

852391-20-9

Research Use Only

99.65

C13H12ClN3O2

277.711

Necrostatin 2 S enantiomer is the S enantiomer of Necrostatin 2. Necrostatin 2 is a potent necroptosis inhibitor, acts as a RIPK1 inhibitor lacking the IDO-targeting effect. Target: RIPK1 [4] Necrostatin 2 is a potent in vitro necroptosis inhibitors (exemplified by 1, EC50-0.05 uM) that also were efficacious in an animal model of ischemic stroke. Many Necroptosis inhibitor derivatives are designed for researchers. Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. It can be induced in a FADD-deficient variant of human Jurkat T cells treated with TNF-a. 5-(1H-Indol-3-ylmethyl)-2-thiohydantoins and 5-(1H-indol-3-ylmethyl)hydantoins were found to be potent necroptosis inhibitors (called necrostatins).

O=C1N(C)C([C@H](CC2=CNC3=C2C=CC=C3Cl)N1)=O

-20°C,2°C to 8°C

12352200