Western blot analysis of extracts of various cell lines using NEDD8 Polyclonal Antibody at 1:1000 dilution.
NEDD8 Polyclonal Antibody
E-AB-60222
Product group Antibodies
Overview
- SupplierElabscience
- Product NameNEDD8 Polyclonal Antibody
- Delivery Days Customer12
- CertificationResearch Use Only
- Scientific DescriptionNedd8 is an 81 amino acid Ub-like protein. It is conjugated to protein substrates in much the same way as Ub, using the E1, E2, E3 cascade. The specific E1 used is a heterodimer of APPBP1/UBA3. Two E2s have been discovered to follow called Ubc12 and Ube2F. Neddylation causes conformational change of the Cullin protein in the E3 called cullin-RING ligases (CRLs), which enhances the E3 Ub ligase activity of CRLs.
- UNSPSC12352203