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Neferine

M4228
AbMole BioScience
CAS Number2292-16-2
Product group Chemicals
Molecular Weight624.77
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Overview

  • Supplier
    AbMole BioScience
  • Product Name
    Neferine
  • Delivery Days Customer
    9
  • CAS Number
    2292-16-2
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Molecular Formula
    C38H44N2O6
  • Molecular Weight
    624.77
  • Scientific Description
    Neferine is a bisbenzylisoquinoline alkaloid extracted from Plumbago officinalis, which reduces lipid accumulation and promotes bèta-oxidation through activation of the AMPK pathway in hepatocytes, and possesses anti-inflammatory, antioxidant, and antipulmonary fibrosis activities. In addition, Neferine potently inhibits NF-kappaB activation.The affinity Kd value of Neferine for ABCB1 is 0.659 uM.It can be used in studies related to non-alcoholic steatohepatitis (NASH).
  • SMILES
    COC1=CC=C(CC2N(C)CCC3=C2C=C(OC4=CC(=CC=C4O)CC5N(C)CCC6=C5C=C(OC)C(=C6)OC)C(=C3)OC)C=C1
  • Storage Instruction
    4°C
  • UNSPSC
    12352200