Nemorubicin (GMP)
HY-15794G
Overview
- SupplierMedChem Express
- Product NameNemorubicin (GMP) [108852-90-0]
- Delivery Days Customer14
- CAS Number108852-90-0
- CertificationResearch Use Only
- Molecular FormulaC32H37NO13
- Molecular Weight643.64
- Scientific DescriptionNemorubicin (Methoxymorpholinyl doxorubicin) GMP is a GMP-class Nemorubicin (HY-15794). Nemorubicin is a Doxorubicin derivative with potent antitumor activity. Nemorubicin is highly cytotoxic to a variety of tumor cell lines presenting a multidrug-resistant phenotype. Nemorubicin not only intercalate into the duplex DNA, but also result in significant ligands for G-quadruplex DNA segments, stabilizing their structure. Nemorubicin requirs an intact nucleotide excision repair (NER) system to exert its activity [1] [2] [3] [4] .
- SMILESCOC1=C2C(C(C3=C(O)C(C[C@](C(CO)=O)(O)C[C@]4([H])O[C@H]5C[C@H](N6CCO[C@H](OC)C6)[C@H](O)[C@H](C)O5)=C4C(O)=C3C2=O)=O)=CC=C1
- UNSPSC12352200