NEO214 [1361198-80-2]

TargetMol Chemicals

NEO214 [1361198-80-2]

16

Research Use Only

C27H35NO5

453.57

NEO214, an autophagy inhibitor and a covalent conjugate of the PDE4 inhibitor Rolipram and perillyl alcohol, exhibits anti-cancer activity and blood-brain barrier (BBB) permeability. It prevents autophagy-lysosome fusion, blocking autophagic flux and triggering glioma cell death via mTOR activation and TFEB (Transcription Factor EB) aggregation. NEO214 inhibition of Macroautophagy/autophagy in glioblastoma cells may overcome chemotherapy resistance in glioblastoma [1].

C(OCC=1CC[C@H](C(C)=C)CC1)(=O)N2CC(CC2=O)C3=CC(OC4CCCC4)=C(OC)C=C3

-20°C

12352200