Nephrin [65136-96-1]

TargetMol Chemicals

Nephrin [65136-96-1]

999

Research Use Only

Nephrin

C30H52O3

460.743

Nephrin is a cell surface signaling receptor protein that regulates podocyte function and plays a role in beta-cell survival signaling; it is a protein necessary for the proper functioning of the renal filtration barrier. Nephrin belongs to a family of highly conserved proteins with a well characterized function as modulators of cell adhesion and guidance, and nephrin may have a role in metabolic pathways linked to podocyte and pancreatic beta-cell survival. Nephrin is associated and partly co-localized with PI3-kinase in mouse islet beta-cells and the mouse pancreatic beta-cell line (betaTC-6 cells). Nephrin silencing abolishes Akt activation and increased susceptibility of cells to apoptosis. Glucose-induced changes in nephrin signaling may contribute to gradual pancreatic beta-cell loss in type 2 diabetes. This suggests a role for nephrin as an independent modulator of podocyte and pancreatic beta-cell nutrient sensing in the fasting state and the potential of nephrin as a drug target in diabetes.

3 years

[H][C@@]12CC[C@]3(C)[C@]([H])(CC[C@]4([H])[C@@]5(C)CCCC(C)(C)[C@]5([H])[C@@H](O)[C@H](O)[C@@]34C)[C@@]1(C)CCC2C(C)(C)O - @@:33 -

-20°C

12352200